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KMID : 0032220110230040468
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Annals of Dermatology
2011 Volume.23 No. 4 p.468 ~ p.743
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IL-31 Serum Protein and Tissue mRNA Levels in Patients with Atopic Dermatitis
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Kim Song
Kim Hyun-Je
Yang Hee-Seung
Kim Eu-Gene
Huh Ik-Soo
Yang Jun-Mo
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Abstract
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Background: Severe pruritus is the primary symptom in atopic dermatitis (AD). Recently, the novel cytokine IL-31 has been implicated in the itching associated with AD.
Objective: We performed this study to determine whether IL-31 serum levels are elevated in AD patients and to better characterize the relationship between serum IL-31 level and other established laboratory parameters.
Methods: We recruited 55 AD patients, 34 with allergic type AD and 21 with non-allergic type AD, and 38 healthy, non-atopic controls. We checked the laboratory values, severity score, and serum IL-31 levels in all patients and controls, and IL-31 mRNA levels in lesion skin were measured in 13 subjects with AD and in four controls.
Results: AD patients displayed significantly higher levels of serum IL-31 that were associated with serum IgE, disease severity, and subjective itch intensity. In AD patients, IL-31 mRNA levels from the lesional skin samples also correlated with serum IL-31 level.
Conclusion: IL-31 is likely one of the many mediators inducing inflammation and pruritus in AD. Although our limited sample size prevents us from making any definitive conclusions, our data demonstrate a strong correlation between IL-31 mRNA level and serum IL-31 protein level, which has never been reported before. Moreover, we found correlations between serum IL-31 level and serum IgE, eosinophil cationic protein, disease severity, and subject itch intensity in certain degrees in AD patients.
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KEYWORD
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Atopic dermatitis, IL-31 mRNA, Itching, SCORAD, Serum IL-31
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